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ba0003pp296 | Osteoporosis: treatment | ECTS2014

Correlation between 25-OH vitamin D, γδTCR lymphocytes and acute phase reaction after the first zoledronic acid infusion for post-menopausal osteoporosis

Massarotti Marco S , Cavaciocchi Francesca , Crotti Chiara , Maria De Santis , Ceribelli Angela , Fabbriciani Gianluigi , Selmi Carlo

Background: Zoledronic acid (ZA) is associated with a transient post-infusional acute phase reaction (APR) due to the activation of γδTCR lymphocytes (γδTcells).Aims: To investigate if APR correlates with γδTcell percentage or cytokine polarization, or with 25-OH vitamin D levels; to identify a 25-OH vitamin D level associated with a lower risk of APR.Methods: Sera for ELISA test (IFNγ, IL17, and ...

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Correlation between 25-OH vitamin D, γδTCR lymphocytes and acute phase reaction after the first zoledronic acid infusion for post-menopausal osteoporosis

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